Abstract. This review provides a qualitative comparative analysis of theoretical and methodological aspects of 27 studies in which the results of the implementation of programs involved in child maltreatment are presented with an attachment perspective. The studies were examined following the Scottish Intercollegiate Guidelines Network. It was found that the programs promote the development of maternal sensitivity, mentalization or reflective functioning and empathy, however, the underlying mechanisms are not differentiated according to the type of abuse to intervene. Likewise, it was found that despite the recognition of the mother's violent childhood experiences as one of the main predisposing factors for child abuse, it is a variable that is scarcely considered in the programs examined. These findings indicate the importance of developing intervention programs that consider a cumulative ecological risk perspective.

Abstract This is a narrative review of azathioprine. This medication is immunomodulatory and immunosuppressive, and it has been used widely through different medical specialties to modify disease. It has been proven useful for several dermatoses and it has encountered success when used as an off-label indication for other dermatologic diseases. Its mechanism of action is described thoroughly, as well as precautions for monitoring adequate levels in patients using it. Dermatologists should also be aware of the possible adverse events it may present. In dermatology it can be used in bullous and autoimmune diseases, and in other conditions, including intractable pruritus, atopic dermatitis, photodermatoses, psoriasis, and others. Azathioprine offers an alternative as a steroid-sparing agent and this review helps dermatologists prescribe it safely to all patients who require it.

Abstract Introduction: Stevia rebaudiana extracts can be used as a sweetener due to their glycoside content: specifically stevioside and rebaudioside. Both compounds have adequate pharmacological characteristics for human consumption. Objective: the aim of this study was to standardize the formulation of marmalades using nopal-pineapple-stevia aqueous extract ratios. Methods: the products were evaluated to determine their physicochemical properties, in vitro inhibition of α-amylase and glycemia in healthy volunteers. Storage study was conducted for 20 days at room temperature 23-30 °C and relative humidity 80-85%. Results: incorporation of stevia significantly modified physicochemical properties like °Brix, color and flow index. After storage, the presence of molds and bacteria were not detected. Sensory evaluation indicated that marmalade with 50% stevia replacement was equally accepted as marmalade with sucrose. Marmalade with 50 and 100% of stevia inhibited 35.89 and 38.50% of the α-amylase activity. After an intake of 30 g, it seems that marmalades with stevia had a significant effect on the glycemia of the volunteers. Conclusions: however, further studies with larger doses of nopal-pineapple-stevia marmalade and consumed for longer in both healthy volunteers and patients with diabetes are needed to achieve results that are more precise.

Resumen Introducción: los extractos de Stevia rebaudiana pueden ser utilizados como edulcorante debido a su contenido de glucósidos: específicamente esteviósido y rebaudiósido. Ambos compuestos presentan características farmacológicas adecuadas para el consumo humano. Objetivos: el objetivo del presente trabajo fue estandarizar formulaciones de mermeladas con diferentes proporciones de nopal-piña-extracto acuoso de stevia. Métodos: se estudiaron las propiedades fisicoquímicas de las mermeladas, su capacidad de inhibir in vitro a la enzima α-amilasa y la glicemia en voluntarios sanos. Los estudios de vida de anaquel se efectuaron durante 20 días a temperatura ambiente 23-30 °C y humedad relativa 80-85%. Resultados: la incorporación de estevia modificó significativamente los grados Brix, el color y el índice de flujo de las mermeladas. Concluido el estudio de anaquel, no se observó la presencia de hongos o bacterias. La evaluación sensorial indicó que la mermelada con 50% de estevia fue aceptada con el mismo nivel de agrado que la mermelada con sacarosa. Las mermeladas con 50 y 100% de estevia inhibieron la actividad de la α-amilasa con valores de 35.89% y 38.50%, respectivamente. Posterior a una ingesta de 30 g de mermelada se observó un efecto significativo en la glicemia de voluntarios sanos. Conclusiones: deberán efectuarse estudios de consumo prolongado y de mayores cantidades de mermelada tanto en voluntarios sanos como con diabetes para obtener resultados más precisos.

Abstract: Cutaneous mucinoses are a heterogeneous group of dermatoses in which excess deposition of mucin in the dermis gives the skin a waxy appearance, with papules and plaques that can vary from self-healing mucinosis to even disrupting the normal shape of a patient’s face, conferring a leonine facies, or be part of life threatening diseases like scleromyxedema. This review will describe the most recent classification on lichen myxedematosus in the generalized (scleromyxedema) and the localized forms, as well as the different organ systems involved in scleromyxedema, diagnostic workup, current management, and prognosis.

The aim of this paper was to evaluate the effects of a strategy of changes to manage the bio-economic efficiency of a Murrah Buffalo production system in the province of Camagüey, Cuba, located 210 north and 770 west, 217 meters above sea level. The climate is tropical humid (Aw) plain. The mean annual precipitations average 1 180 mm (71 % between May and October), and temperature is between 24 and 29° C. The local soil is carbonated brown, brown without carbonates, and reddish-brown fersiallitic. The system comprises 5 100 ha and has 536 workers/year. A strategy to introduce management changes in agro-technology, food, reproduction, replacement, health, salary policies, and training was implemented as part of an innovation package with a systemic and participatory approach. The evaluation lasted eight years, and it was critical to increase dairy production in more than 200 000 kg/year in 2012, in comparison to 2004, with improvements in natality and reduction of operational expenses of the system. It was concluded that the strategy had a determining effect on the system's indicators.

El objetivo del trabajo fue evaluar los efectos de una estrategia de cambios en el manejo en la eficiencia bio-económica de un sistema cooperativo de producción de Búfalos Murrah de Camagüey en Cuba, localizado en los 210 Norte y los 770 Oeste a 217 msnm. El clima es tropical húmedo (Aw) de llanura. La media anual de las precipitaciones fue de 1 180 mm (71 % de mayo a octubre) y temperaturas entre 24 y 29° C. El suelo es pardo carbonatado, pardos sin carbonatos y fersialíticos pardo rojizos. El sistema ocupa un área de 5 100 ha y emplea 536 trabajadores/año. Una estrategia de cambios en el manejo agro-técnico, alimentario, reproductivo, de reemplazos, en salud, política de salarios y determinadas acciones de capacitación fue puesta en práctica como una especie de paquete innovador con enfoque sistémico y participativo. La evaluación se desarrolló durante ocho años y fue determinante en el incremento de la producción de leche en más de 200 000 kg/año en el 2012 respecto al 2004, con una mejora en la natalidad y reducción en los gastos operacionales del sistema. Se concluye que la estrategia tuvo un efecto determinante en el comportamiento favorable de los indicadores del sistema.

To evaluate the factors that affect efficiency in a Leucaena leucocephala cv Perú association with pastures for bovine fattening, 22 Zebu fattening cycles were studied on a farm of the Rectángulo Livestock Company, in Camagüey, Cuba, between 2002 and 2012. The local soil is brown without carbonates. The climate is tropical humid, and annual precipitation averages 1 183 mm . The factors evaluated were, food balance, duration of the fattening cycle, and quantity of animals/cycle. The daily weight gain and expenses/income per operation were also analyzed. The pasture and Leucaena percents were determined by plant counts. Food balances were made. Leucaena cv Perú reached final values of 93 % (P < 0.05) with an increase in common Bermuda grass and others. Short duration tests showed much higher gains (P < 0.05), with values above 1.0 kg/animal/day. The number of animal/cycle (P < 0.05) produced higher gains with fewer animals. Forest grazing in association with Leucaena leucocephala cv Perú-graminaeae in drylands produced mean daily gains above 0.800 kg/animal/day in the final stage of fattening bulls, according to food balances with adequate biological and economic results, and the best behavior in the shortest cycles, where the highest final weight/animal values were achieved, with fewer expenses and higher income.

Con el objetivo de evaluar factores que afectan la eficiencia en una asociación de Leucaena leucocephala cv Perú con pastos para ceba final de bovinos, se analizaron desde el 2002 al 2012, 22 ciclos de ceba de toros Cebú en una finca de la Empresa Pecuaria Rectángulo de ceba en Camagüey, Cuba. El suelo es Pardo sin Carbonatos. El clima es tropical húmedo (Aw) y precipitación anual de 1 183 mm . Los factores evaluados fueron: balance alimentario, duración de ciclo de ceba y cantidad de animales/ciclo. Se analizaron índices de ganancia diaria de peso, gastos e ingresos por operación. Se determinaron los por cientos de pastos y Leucaena por conteo de plantas. Se realizaron balances alimentarios. Leucaena cv Perú alcanzó valores finales del 93 % (P < 0,05) en su población, con incremento de Guinea común y otros pastos. Las pruebas de corta duración logran ganancias muy superiores (P < 0,05) con valores por encima de 1,0 kg/animal/día. El número de animales/ciclo afectó (P < 0,05) por mayores ganancias con menos animales. La tecnología de silvopastoreo con asociación de Leucaena leucocephala cv Perú-gramíneas en secano, permitió obtener ganancias medias diarias por encima de 0,800 kg/animal/día en toros de ceba final evaluadas por balances alimentarios con resultados biológicos y económicos muy adecuados y el mejor comportamiento para los ciclos más cortos, donde se obtuvieron los mayores pesos finales/animal, con menos gastos por suplementos y mayores ingresos.

ABSTRACT Background: Infection with Human T cell Leukemia Virus type 1 can be associated with myelopathy/tropical spastic paraparesis (HAM/TSP) and other inflammatory diseases. Lymphocytes from about half of Human T cell Leukemia Virus type 1-infected subjects spontaneously proliferate in vitro, and how this phenomenon relates to symptomatic disease and viral burden is poorly understood. Objective: To evaluate T-cell proliferation in vitro among patients co-infected with Human T cell Leukemia Virus type 1/Hepatitis C Virus/Human Immunodeficiency Virus type 1. Material and methods: From 610 Human T cell Leukemia Virus-infected patients of the Human T cell Leukemia Virus outpatient clinic from Institute of Infectious Diseases “Emilio Ribas” in São Paulo, 273 agreed to participate: 72 had HAM/TSP (excluded from this analysis) and 201 were asymptomatic, a classification performed during a regular neurological appointment. We selected the subgroup made up only by the 201 asymptomatic subjects to avoid bias by the clinical status as a confounder effect, who had laboratory results of Human T cell Leukemia Virus type 1 proviral load and T-cell proliferation assay in our database. They were further grouped according to their serological status in four categories: 121 Human T cell Leukemia Virus type 1 asymptomatic mono-infected carriers; 32 Human T cell Leukemia Virus type 1/Hepatitis C Virus, 29 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1, and 19 Human T cell Leukemia Virus type 1/Human Immunodeficiency Virus type 1/Hepatitis C Virus co-infected patients. Clinical data were obtained from medical records and interviews. DNA Human T cell Leukemia Virus type 1 proviral load (PVL) and T-cell proliferation (LPA) assay were performed for all samples. Results: From a total of 273 subjects with Human T cell Leukemia Virus type 1, 80 presented co-infections: 29 had Human Immunodeficiency Virus type 1, 32 had Hepatitis C Virus, and 19 had Human Immunodeficiency Virus type 1 and Hepatitis C Virus. Comparing the groups based on their serological status, independently of being asymptomatic carriers, we observed a significant increase of PVL (p < 0.001) and LPA (p = 0.001). However, when groups were stratified according to their clinical and serological status, there was no significant increase in Human T cell Leukemia Virus type 1 PVL and LPA. Conclusion: No significant increase of basal T-cell proliferation among Human T cell Leukemia Virus type 1 co-infected was observed. This interaction may be implicated in liver damage, worsening the prognosis of co-infected patients or, on the contrary, inducing a higher spontaneous clearance of Hepatitis C Virus infection in Human T cell Leukemia Virus type 1 co-infected patients.

With the objective of determining the productive reach in bovine Cebú when using as supplement Norgol + molasses-urea to 3 % during the stage of growth-it feeds low shepherding system, 60 properly uniformed toretes was used as for weight and characteristic racial conforming to subjected four experimental groups at nine daily hours of shepherding, on grass PITILLA (Dichantium annulatum) + Tejana (Paspalum notatun) of regular quality; 3 kg of forage of Penisetum Cuba CT - 115; 1.0, 1.5 and 2.0 kg of Norgold for the groups I, II, III and IV, respectively and salt mineral and it dilutes ad libitum. The weight alive initial was determined and final, absolute growth, daily half gain and I consummate as well as was considered the benefit/cost. The animals of the treatment four were able to reach 401 kg of live weight , that is to say, 47.43 % of their weight regarding the weight live initial in 180 days and like average, for the whole period, a daily half gain and conversion of 716.66 g and 10.37 food kg / kg of weight lives respectively. It concludes that the treatments where it is included 2.0 and 1.5 Norgold kg respectively they achieved earnings daily stockings and conversion alimentary superiors significantly (P < 0.05) to the systems that traditionally have been orchestrated with the help of molasses-urea and the employment of other by-products, as well as the meat production that is achieved allows a relationship positive benefit / cost, that which means that the system is feasible, productive and economic.

Con el objetivo de determinar el alcance productivo en bovinos cebú al utilizar como suplemento Norgold + melaza-urea al 3 % durante la etapa de crecimiento-ceba bajo sistema de pastoreo, se emplearon 60 toretes, de iguales pesos y características raciales, conformándose cuatro grupos experimentales; sometido a 9 h diarias de pastoreo, sobre pasto pitilla (Dichantium annulatum) + tejana (Paspalum notatum) de calidad regular; 3 kg de forraje de Penisetum Cuba CT - 115; 1,0; 1,5 y 2,0 kg de Norgold para los grupos I, II, III y IV, respectivamente y sal mineral y agua ad libitum. Se determinó el peso vivo inicial y final, crecimiento absoluto, ganancia media diaria y consumo, así como se estimó el beneficio/costo. Los animales del tratamiento 4 lograron alcanzar 401 kg de peso vivo; es decir, el 47,43 % de su peso respecto al peso vivo inicial en 180 días, y como promedio para todo el período, una ganancia media diaria y conversión de 716,66 g y 10,37 kg de alimento/kg de peso vivo, respectivamente. Se concluye que los tratamientos donde se incluye 2,0 y 1,5 kg de Norgold, respectivamente, lograron ganancias medias diarias y conversión alimentaria superiores (P< 0,05) a los sistemas tradicionales con base de melaza-urea y otros subproductos, así como la producción de carne que se logra permite una relación costo/beneficio positiva, lo cual significa que el sistema es factible, productivo y económico.

In this area was applied three doses of selenium and zinc (0.0; 1.0 and 1.5 cc), under a (DCA) in factorial arrangement (3 x 2) + (3 x 2) in order to analyze the effect of the level of additional mineral supplement micro (Selenium, Zinc) to the diet on the raised variables, weight and fiber diameter of alpacas. Results revealed statistical differences for treatment: selenium doses, age, Zinc doses, Zinc interaction for ages. For this, the treatment 4 (Se1E2) with 74.33 kg to 90 days to cross height (Zn1E2) with 91.33 cm average. The length fiber into treatments 3 (Se1E1) and 4 (Se1E2) with 3 cm average. For fiber diameter on treatments 1 (Se0E1) Treatment 3 (Se1E1) of group 1, treatments 8 (Zn0E2) and 9 (Zn1E1) which group 2 charged better fiber quality with 28 microns average. It was confirmed an beneficial effect on live weight and fiber quality in mature animals for mineral supply with Se and Zn con los microelements, that improved the production phenotypical characteristics like weight, but it was manifested minerals urine residuality in 3-5 years old animals.

Con el objetivo de analizar el efecto del nivel de suplemento de microminerales adicionales a la dieta sobre las variables alzada peso y diámetro de la fibra de alpacas, se evaluó la aplicación de tres dosis de selenio y zinc (0,0; 1,0 y 1,5 cc), bajo un (DCA) en arreglo factorial (3 x 2) + (3 x 2). Los resultados mostraron diferencias estadísticas para tratamientos: dosis de selenio, edades, dosis de zinc, edades y para la interacción zinc por edades (Se1E2 con 74,33 kg a los 90 días para alzada a la cruz, Zn1E2 con un promedio de 91,33 cm). La longitud de la fibra los tratamientos Se1E1 y Se1E2 con promedio de 3 cm. Para el diámetro de la fibra los tratamientos 1 (Se0E1) y tratamiento Se1E1 del grupo 1 y los tratamientos Zn0E2 y Zn1E1 del grupo 2 mostraron mejor calidad de la fibra (P < 0,05), con promedios de 28 micras. Se confirmó un efecto beneficioso en el peso vivo, calidad de la fibra en animales maduros de la suplementación con los microelementos Se y Zn, que mejoró las características fenotípicas de producción como el peso vivo, aunque manifestó residualidad en la orina de los animales de 3 a 5 años de edad.

From the environmental assessment conducted in the centrifugation process fuel that is used as raw material for generating electricity in Power Plants (CE) operating with diesel and the physicochemical characterization of oleaginuos water (ARO) that it generates, it was performed the environmental impact assessment of these waters if they are discharged without any treatment. A matrix of importance was made, which allowed us to identify the impact on the actions and factors by the activity and the generated waste. From the physico-chemical characterization of ARO, a sustainable treatment is proposed with the use of a fixed-bed column filled with sugar cane bagasse as biosorbent material to minimize the environmental impact caused by oleaginous water if spilled. A physicochemical characterization was made to the natural sugar cane bagasse in terms of moisture, density, porosity and high adsorption capacity. The results allowed to define the fraction of interest (+1 -2 mm), given by the performance in the screening (41%), the homogeneity of this fraction and sorption capacity (2g diesel/g BN). The breakthrough curve was obtained by a continuous flow system 2 l/h of ARO through a fixed bed of 59.997 g of BN and an initial concentration of hydrocarbon of 1444.9 mg/l. Studies showed that the sugarcane bagasse has potential as biosorbent oil, achieving a significant removal of the indicator total hydrocarbon, of 65%.

A partir del diagnóstico ambiental realizado en el proceso de centrifugación del combustible utilizado como materia prima para la generación de energía eléctrica en las Centrales Eléctricas (CE) que operan con diesel y la caracterización físico-química del agua residual oleosa (ARO) que se genera, se realizó la evaluación de impacto ambiental que estas aguas provocan si son vertidas el medio sin tratamiento alguno. Se confeccionó una matriz de importancia que permitió identificar las acciones y factores impactados por la actividad y los residuos generados. Partiendo de la caracterización físico-química del ARO se propone un tratamiento sustentable con la utilización de una columna de lecho fijo rellena con bagazo de caña de azúcar como material biosorbente, para minimizar el impacto ambiental provocado por las aguas oleosas en caso de derrame. Al bagazo de caña de azúcar natural (BN) se le realizó una caracterización físico-química: humedad, densidad aparente, porosidad y capacidad máxima de adsorción. Con los resultados obtenidos se definió la fracción de interés (+1 -2 mm), dado por el rendimiento en el tamizado (41%), la homogeneidad de dicha fracción y su capacidad de sorción (2g diesel/g BN). La curva de ruptura se obtuvo mediante un sistema de flujo continuo de 2 L/h de ARO a través de un lecho fijo de 59,997 g de BN y una concentración inicial de hidrocarburo de 1444,9 mg/L. Los estudios demostraron que el bagazo de caña de azúcar tiene potencialidades como biosorbente de hidrocarburos, lográndose una remoción significativa del indicador hidrocarburo total, de un 65%.

The present article provides a literature review about the biological potential of Melipona beecheii. The objective is to project some tendecies in research about nutraceutical aspects related to the bioactive compounds presents in the honey of this stingless bee species, known for its medicinal properties traditional, in the Yucatan Peninsula. Currently, there is strong evidence that M. beecheii honey has bioactive compounds such as proteins, flavonoids and polyphenols with high antioxidant activity. The scientific evidence allows to propose to the honey of stingless bee species as a potential alternative for the obtention of bioactive compounds with antioxidant activity in the Yucatan Peninsula and natural food being proposed to reduce some diseases associated with stress oxidative physiological human cells. However, there is still information that explains such antioxidant activity, therefore, according to the literature reviewed, sees the need to address nutraceuticals and functional aspects correlated with the bioactive compounds present in this honey bee.

El presente artículo provee una revisión de literatura sobre el potencial biológico de la miel de Melipona beecheii. El objetivo es proyectar algunas tendencias en investigación sobre los aspectos nutracéuticos relacionados con los compuestos bioactivos presentes en la miel de esta especie de abeja sin aguijón, reconocida por sus características medicinales tradicionales, en la Península de Yucatán. Actualmente existe una evidencia sólida que demuestra que la miel de M. beecheii posee compuestos bioactivos tales como proteínas, flavonoides y polifenoles, con alta actividad antioxidante. La evidencia científica obtenida permite proponer a la miel de esta especie de abeja sin aguijón como alternativa para la obtención de compuestos bioactivos con actividad antioxidante en la Península de Yucatán, y ser propuesto como alimento natural para reducir algunos tipos de cáncer asociados al estrés oxidativo de las células fisiológicas del ser humano. Sin embargo, aún falta información que explique dicha actividad antioxidante; por lo tanto, de acuerdo con la literatura revisada, se ve la necesidad de abordar aspectos nutracéuticos y funcionales en correlación con los compuestos bioactivos presentes en esta miel de abeja.

The recent introduction of the cultivation of Stevia rebaudiana Bertoni in Mexico has gained interest for its potential use as a non-caloric sweetener, but some other properties of this plant require studies. Extracts from two varieties of S. rebaudiana Bertoni adapted to cultivation in Mexico were screened for their content of some phytochemicals and antioxidant properties. Total pigments, total phenolic and flavonoids contents of the extracts ranged between 17.7-24.3 mg/g, 28.7-28.4 mg/g, and 39.3-36.7 mg/g, respectively. The variety "Criolla" exhibited higher contents of pigments and flavonoids. Trolox equivalent antioxidant capacity ranged between 618.5-623.7 mM/mg and DPPH decolorization assay ranged between 86.4-84.3%, no significant differences were observed between varieties. Inhibition of â-carotene bleaching ranged between 62.3-77.9%, with higher activity in the variety "Criolla". Reducing power ranged between 85.2-86% and the chelating activity ranged between 57.3-59.4% for Cu2+ and between 52.2-54.4% for Fe2+, no significant differences were observed between varieties. In conclusion, the results of this study showed that polar compounds obtained during the extraction like chlorophylls, carotenoids, phenolic compounds and flavonoids contribute to the antioxidative activity measured. The leaves of S. rebaudiana Bertoni could be used not only as a source of non-caloric sweeteners but also naturally occurring antioxidants.

La reciente introduccion del cultivo de Stevia rebaudiana Bertoni en Mexico ha ganado interes debido a su potencial uso como fuente de edulcorantes no caloricos, pero otras propiedades de esta planta aun requieren de estudios. Extractos de hojas de dos variedades de S. rebaudiana Bertoni adaptadas al cultivo en Mexico fueron evaluados en cuanto a su contenido de algunos fitoquimicos y sus propiedades antioxidantes. El contenido de pigmentos, fenoles totales y flavonoides en los extractos, oscilo entre 17.7-24.3 mg/g, 28.7-28.4 mg/g, y 39.3-36.7 mg/g, respectivamente. La variedad �"Criolla�" exhibio los mayores contenidos de pigmentos y flavonoides. La capacidad antioxidante equivalente de Trolox oscilo entre 618.5-623.7 mM/mg y el ensayo de decoloracion del radical DPPH oscilo entre 86.4-84.3%, no observandose diferencias significativas entre ambas variedades. La inhibicion de la decoloracion del β-caroteno oscilo entre 62.3-77.9%, siendo mayor en la variedad �"Criolla�". El poder reductor oscilo entre 85.2-86%, las capacidades quelantes de cobre y hierro oscilaron entre 57.3-59.4% y 52.2-54.4%, respectivamente, no observandose diferencias significativas entre ambas variedades. En conclusion, los resultados de este estudio demuestran que los compuestos de naturaleza polar obtenidos durante la extraccion, tales como pigmentos clorofilicos, carotenoides, compuestos fenolicos y flavonoides contribuyen a la actividad antioxidante. Las hojas de S. rebaudiana Bertoni podrian ser empleadas no solo como fuente de edulcorantes no caloricos, sino tambien como fuente de antioxidantes de origen natural.